FACT Complex: Protein-Protein Interaction and Disease Implications

Target Name: FACT complex

NCBI ID: P15424

Other Name(s): None

FACT Complex: Protein-Protein Interaction and Disease Implications

The FACT complex is a protein family that plays a crucial role in various cellular processes, including cell adhesion, migration, and invasion. It is composed of four subunits: FAT (focal adhesion protein), TGF-β1 (transforming growth factor 尾1), PDGFR-尾1 (PD-growth factor receptor 尾1), and PLC/PKC (phosphorylcholine synthase/phosphorylcholine kinase). The FACT complex has been implicated in various diseases, including cancer, neurodegenerative diseases, and developmental disorders.

The FACT complex is a protein-protein interaction (PPI) domain and contains several unique structural features that give it a unique structure. It has a long extracellular domain that contains a N-terminal flectable region and a C-terminal region that is involved in the formation of a dimer. The N-terminal region contains a putative transmembrane domain (TMD) that is important for the stability of the complex and for its ability to interact with various signaling molecules. The C-terminal region has a conserved catalytic core and contains a unique structural feature called a N-terminal extension that is involved in the formation of a hydrogen bond with the TMD.

The FACT complex has been shown to play a role in various cellular processes, including cell adhesion, migration, and invasion. It is involved in the formation of tight junctions, which are a type of cell-cell adhesion that helps to maintain tissue structure and function. The FACT complex is also involved in the formation of cell migration, which is critical for the development and maintenance of tissues and organs.

In addition to its role in cell adhesion and migration, the FACT complex has also been shown to play a role in the regulation of cell survival. Studies have shown that the FACT complex is involved in the regulation of cell survival by controlling the levels of various cellular signaling pathways, including the TGF-β signaling pathway. TGF-β is a cytokine that plays a critical role in the regulation of cell growth, differentiation, and survival. The FACT complex has been shown to regulate the levels of TGF-β by interacting with its downstream signaling molecules, including the SMAD family of proteins.

The FACT complex has also been implicated in the development and progression of various neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Studies have shown that the FACT complex is involved in the regulation of neurodegenerate protein synthesis and that it plays a role in the development of neurodegenerate diseases.

In conclusion, the FACT complex is a protein family that has been implicated in various diseases, including cancer, neurodegenerative diseases, and developmental disorders. Its unique structure and various functions make it a potential drug target or biomarker. Further research is needed to fully understand the role of the FACT complex in various cellular processes and to develop effective therapies for these diseases.

Protein Name: FACT Complex

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